替格瑞洛对阿司匹林抵抗冠心病患者的疗效

The Treating Effect of Ti Gray Lo to Aspirin Resistance Patients With Coronary Heart Disease

目的探讨替格瑞洛对阿司匹林抵抗冠心病患者的治疗效果。方法收集该院阿司匹林抵抗的冠心病患者58例,按照数字法随机分两组,对照组2 9例继续服用阿司匹林抗血小板聚集,观察组2 9例给予替格瑞洛抗血小板聚集,10 d后观察两组患者血小板聚集情况及出血发生情况。结果观察组患者血小板集聚率(3 9.48±3.62)%较对照组血小板集聚率(59.3 7±5.96)%明显降低,差异有统计学意义(P<0.0 5);观察组患者血小板集聚率下降值(19.2 8±6.2 8)%大于对照组血小板集聚率下降值(2.10±1.98)%,两组比较差异有统计学意义(P<0.0 5);观察组患者血小板集聚率达标率(87.56%)高于对照组血小板集聚率达标率(5.70%),两组比较差异有统计学意义(P<0.0 5)。两组均无出血并发症发生。结论替格瑞洛可以明显降低阿司匹林抵抗的冠心病患者血小板集聚率,同时并不增加出血并发症发生率。

Objective To Discuss for green Luo on aspirin resistance in patients with coronary heart disease treatment effect. Methods Collect 58 resistance in patients with coronary heart disease in our hospital pa- tients in accordance with aspirin, the digital method were randomly divided into two groups, the control group 29 cases to continue taking aspirin, the observation group 29 cases was given for the green Luo antiplatelet, 10 days after the 2 groups were observed in patients with platelet aggregation and bleeding situation. Results The observation group patients platelet aggregation rate（39.48±3.62）% compared with the control group, the platelet aggregation rate of early （59.37±5.96）% of early decreased significantly,the difference was statisti- cally significant （P〈0.05） ;the observation group patients platelet aggregation rate decreased value （ 19.28±6.28 ）% than the control group of early platelet aggregation rate decreased valu（2.10±1.98）%, there was sig- nificant difference between 2 groups （P〈0.05）; the observation group patients platelet aggregation rate （87.56%） was higher than that of control group,platelet aggregation rate（5.70%）, there was significant dif- ference between 2 groups （P〈0.05）. The 2 groups were no bleeding complications. Conclusions For the green Luo can obviously reduce the platelet aggregation rate in patients with coronary heart disease, aspirin resistance, and doesn＇t increase the incidence rate of complications of blood.