摘要
[目的]在新农药创制研究中,寻找高活性化合物。[方法]利用"中间体衍生化"方法,经设计、合成了12个2-氯-N-[6-(3-氯-苯氧基)-吡啶-3-基甲基]-烟酰胺类化合物。以2-氯-5-氰基吡啶为起始原料经多步反应生成目标化合物,所有结构均经核磁共振氢谱验证,并对合成的化合物进行了室内杀菌活性筛选。[结果]初步生物活性测试结果表明:在普筛条件下此类化合物有良好的杀菌活性,质量浓度为400 mg/L时,化合物C4、C12表现出良好的广谱杀菌性。
[Aims] The paper aims to find new compounds with highly bioactivity. [Methods] Twelve target compounds were designed and synthesized from the starting material of 2-chloro-5-cyanopyridine by using intermediate derivatization method. The structures of target compounds were confirmed by 1H NMR. All the compounds were tested of indoor fungicidal activity. [Results] The bioassay showed that most of them have favorable bactericidal activity. And the compound C4 and C12 exhibited broad-spectrum bactericidal activity at the concentration of 400 mg/L.
出处
《农药》
CAS
CSCD
北大核心
2015年第5期321-323,共3页
Agrochemicals
基金
河南省科技发展计划项目(134300510072)
关键词
2-氯-5-氰基吡啶
中间体衍生化法
合成
生物活性
2-chloro-5-cyanopyridine
intermediate derivatization method
synthesis
biological activity
