卒中后抑郁与卒中部位的相关性研究

Poststroke depression and location of brain lesion

目的：研究不同的脑损伤部位与脑卒中后抑郁（post-stroke depression，PSD）之间的关系。方法：选取2012年9月～2013年9月438例脑卒中患者，全部通过临床症状及MRI检查对病灶定位，使用汉密尔顿抑郁量表（HAMD）对卒中患者进行抑郁评分，分析PSD与卒中部位的关系。结果：162例脑卒中患者合并PSD，总患病率为43．2％；其中女性患者PSD的患病率为54．80％，男性患者的患病率为32．83％，两者差异有统计学意义（X^2=18．39，P〈0．05）；多发性、左侧病灶、额叶、颞叶及基底节区非腔梗性卒中患者PSD患病率较高。结论：PSD发生与年龄、文化程度及卒中类型无关，而与性别及卒中部位存在关联性。

ObJectlve：To investigate the relationship between poststroke depression （PSD） and location of brain lesion. Methods：The relationship between PSD and brain stroke lesion location was analyzed in 438 patients undergone MRI examination for the lesion location between September 2012 and 2013. Hamilton Depression Scale（HAMD） was used to the evaluate the severity of depression. Results： Of the total 438 cases, 162 were present with PSD （ 43.2 % ） , in whom 54. 80 % were women and 32.83 % men, with gender difference （ X2 = 18.39, P 〈 0. 05 ）. The location of brain lesion was most associ- ated with multiple stroke,left-hemisphere, frontal and temporal lobe, basal ganglia stroke and non-lacunar stroke. Conclusion ： PSD has no relation to ages, educational level and type of stroke, whereas is associated with gender and location of brain lesion.