福辛普利钠对糖耐量受损高血压患者多项指标的改善作用

Research on Improvement Effect of Fosinopril Sodium on Multiple Indicators in Hypertensive Patients with Impaired Glucose Tolerance

目的探讨福辛普利钠治疗糖耐量受损高血压患者的疗效。方法选取2013年1月至2014年9月在医院诊治的原发性高血压合并糖耐量减低患者124例,随机均分为治疗组和对照组,各62例。治疗组给予福辛普利钠片治疗,对照组给予硝苯地平缓释片治疗,疗程均为24周,观察记录血压、心率、血糖、胰岛素及血脂变化,评价临床疗效及安全性。结果治疗2周后,治疗组总有效率为90.32%,对照组总有效率为88.71%,组间无明显差异(P>0.05);治疗24周后,两组患者收缩压(SBP)和舒张压(DBP)均较治疗前明显降低(P<0.05),而组间无明显差异(P>0.05),心率(HR)均较治疗前无明显变化(P>0.05);治疗组血糖、胰岛素、血脂等指标均较治疗前明显改善(P<0.05),且明显优于对照组(P<0.05);治疗组不良反应发生率4.84%与对照组的6.45%无明显差异(P>0.05)。结论福辛普利钠用于糖耐量受损高血压患者的治疗,疗效可靠,血压控制理想,且不增加心率,还能降低血糖、胰岛素及血脂水平,改善胰岛素抵抗,不良反应较少,值得临床推广。

Objective Study the effect of fosinopril sodium in the treatment of hypertensive patients with impaired glucose tolerance. Methods 124 hypertensive patients with impaired glucose tolerance in our hospital from January 2012 to September 2013 were select- ed and randomly divided into the treatment group and the control group, 62 cases in each group. The treatment group was treated by Fosinopril Sodium Tablets, while the control group was given Nifedipine Sustained Release Tablet. The treatment course was 24 weeks. The changes of blood pressure, heart rate, blood glucose, insulin and lipid were observed and recorded. The clinical efficacy and safety were evaluated. Results The total effective rate after 2-week treatment was 90. 32% in the treatment group and 88.71% with- out statistically significant difference between the two groups（ P 〉 0. 05）; SBP and DBP after 24 weeks in the two groups were signifi- cantly decreased compared with before treatment（P 〈 0.05）, but no statistical difference between the two groups was found（P 〉 0.05）, while HR had no obvious change compared with before treatment（P 〉 0. 05）; blood glucose, the indicators of insulin and blood lipids were significantly improved compared with before treatment（P 〈 0.05）, while the control group had no significant change in these indicators（P 〉 0. 05）; the occurrence rate of adverse reactions was 4.84% in the treatment group and 6. 45% in the control group without statistical difference between the two groups（ P 〉 0.05）. Conclusion Fosinopril sodium for treating hypertensive patients with impaired glucose tolerance has reliable effect, blood pressure control is ideal without increasing the heart rate, also decreases the blood glucose, insulin and lipid levels, improve insulin resistance, has fewer adverse reactions and deserves to be popularized in clinic.