不同剂量缩宫素对子宫肌瘤血供的影响

Study on Effects of Different Doses of Oxytocin on Uterine Fibroids Blood Supply

目的探讨不同剂量缩宫素对子宫肌瘤血供的影响。方法选取2013年6月至2014年6月因子宫肌瘤拟行超声消融治疗的200例患者,随机分为3组,分别予以缩宫素0.12,0.24,0.36 U/min静脉滴注,观察3组患者静脉滴注缩宫素前后周边动脉和内部动脉血流参数变化,以及生命体征变化和3个月内并发症发生率。结果 3组患者静脉滴注缩宫素后周边动脉、内部动脉平均血流速度(Vmean)、收缩期峰值流速(PSV)、管径和血流量均显著下降,阻力指数(RI)显著上升(P<0.05),但组间内部动脉、周边动脉各指标差异不显著(P>0.05)。3组患者静脉滴注缩宫素后的收缩压、舒张压和平均动脉压均显著低于静脉滴注前,而心率显著高于静脉滴注前(P<0.05),但组间各指标差异不显著(P>0.05)。随访3个月3组患者均未发生包括头晕、恶心呕吐、胸闷、腹痛等在内的并发症。结论静脉滴注缩宫素可减少子宫肌瘤血供,改变超声下血流信号参数。

Objective To investigate the effect of different doses of oxytocin on uterine fibroids blood supply. Methods 200 patients with uterine fibroids undergoing ultrasound ablation in our hospital from June 2013 to June 2014 were selected and randomly divided into three groups. Oxytocin was intravenously dripped by a rate of 0. 12, 0. 24 and 0. 36 U/min. The changes of peripheral arterial and internal arterial blood flow parameters before and after intravenous drip of oxytocin were observed in the three groups. The changes of the vital signs before and after intravenous drip of oxytocin and the occurrence rate of complications within three months were observed in the three groups. Results The mean flow velocity （ Vmean ） , peak systolic velocity （ PSV ） , vascular diameter and blood flow in pe-ripheral and internal arteries after intravenous drip of oxytocin in three groups were significantly decreased, the resistance index （ RI ） was significant increased （ P 〈 0. 05 ）; but the internal and peripheral arterial indexes had no statistically significant differences among the three groups （ P 〉 0. 05 ） . The systolic, diastolic, and mean arterial pressure after intravenous drip of oxytocin in the three groups were significantly lower than those before intravenous drip, while the heart rate was significantly higher than that before intravenous drip （ P 〈0. 05 ）;but no statistically significant differences existed among the three groups （ P 〉 0. 05 ） . No complications including dizziness, nause-a, vomiting, chest tightness, abdominal pain etc. occurred during 3-month follow up period. Conclusion Intravenous drip of oxytocin can reduce the blood supply of uterine fibroids and change the blood flow signals parameters under ultrasound.