头孢硫脒治疗老年呼吸道革兰阳性细菌感染60例

Observation on Effect of Cefathiamidine in Treating Elderly Respiratory Gram-Positive Bacterial Infection in 60 Cases

目的观察头孢硫脒治疗老年患者呼吸道革兰阳性细菌感染的临床疗效。方法将60例革兰阳性细菌感染的呼吸道疾病老年患者应用头孢硫脒(仙力素)静脉滴注治疗。结果治疗后,支气管扩张并感染患者显效率最高(100%),其次是扁桃体炎、慢性支气管炎急性期患者,细菌性肺炎患者治疗显效率最低,明显低于支气管扩张并感染患者(P<0.05);不同菌种阴转率由高到低分别为肠球菌、金黄色葡萄球菌、溶血性链球菌、肺炎链球菌、表皮葡萄球菌,表皮葡萄球菌阴转率与其他各菌种阴转率比较,具有显著差异(P<0.05)。结论头孢硫脒治疗老年呼吸道革兰阳性细菌感染有效、安全,但临床治疗时仍应根据微生物学检查结果,针对感染菌种用药,以便提高致病菌对用药的敏感性。

Objective To observe the clinical efficacy of cefathiamidine in treating of elderly respiratory Gram bacterial infection to pro-vide the basis for the clinical medication. Methods 60 elderly patients with respiratory disease infected by Gram-positive bacteria were intravenously dripped by cefathiamidine and the effects were observed. Results After the cefathiamidine treatment, the patients with bronchiectasis and infection had the highest significantly effective rate of 100%, followed by tonsillitis and acute stage of chronic bron-chitis, the patients with acute bacterial pneumonia had the lowest significantly effective rate, which was significantly lower than that in the patients with bronchiectasis and infection;the bacterial negative conversion rates of different bacteria from high to low were Entero-coccus, Staphylococcus aureus, hemolytic streptococcus, Streptococcus pneumoniae and Staphylococcus epidermidis; there was statistically significant difference in the negative conversion rate between Staphylococcus epidermidis and other bacteria （ P〈 0. 05 ） The strains neg-ative rate with a significant difference （ P〈 0. 05 ） . Conclusion Cefathiamidine has the effect and safety in the treatment of elderly respiratory Gram-positive bacterial infections, but the clinical treatment should use antibacterial drugs according to the microbiological detection results and corresponding infected bacteria in order to increase the pathogenic bacterial susceptibility to drugs.