干扰素雾化联合常规治疗对小儿疱疹性咽峡炎的系统评价

Aerosolized Interferon Combined with Conventional Treatment for Pediatric Herpangina:A Systematic Review

目的系统评价干扰素雾化联合常规治疗对小儿疱疹性咽峡炎的疗效。方法计算机检索Cochrane图书馆(2014年第2期)、MEDLLNE、EMBase、Pub Med、中国期刊全文数据库、中国生物医学文献数据库、中文科技期刊全文数据库(各数据库检索时间均从创建至2014年2月)关于干扰素雾化联合常规治疗对小儿疱疹性咽峡炎的随机对照试验。由2名数据员按纳入与排除标准独立筛选试验,并对纳入研究的方法学质量进行评价,提取资料;用Rev Man5.14软件对数据进行Meta分析。结果共纳入14篇随机对照实验,包括2076名患者。结果与对照组比较,干扰素雾化组总有效率优于常规治疗组〔RR=6.04,95%CI(4.36,8.37),P<0.00001〕,干扰素雾化组退热时间短于常规治疗组〔MD=-1.30,95%CI(-1.80,-0.80),P<0.00001〕,干扰素雾化组疱疹消失时间短于常规治疗组〔MD=-1.77,95%CI(-2.19,-1.36),P<0.00001〕,差异均有统计学意义。结论基于现有临床证据,干扰素雾化联合常规治疗对小儿疱疹性咽峡炎有效,安全性好。但由于纳入研究数量较少,研究质量不统一,本结论尚需要更多大样本、高质量临床随机对照试验予以证实。

Objectiive To evaluate the effectiveness and safety of aerosolized interferon combined with conventional treatment for pediatric herpangina.Methods The Cochrane Library（Issue 2,2014）,EMbase,Pub Med,CBM,CNKI and VIP（from their inception to February 2014） for RCTs of aerosolized interferon combined with conventional treatment for pediatric herpangina were searched.Two reviewers independently retrieved RCTs according to the inclusion and exclusion criteria,assessed the methodological quality of included trials,and extracted data.Data analysis was performed by Rev Man 5.14 software.Results Fourteen RCTs involving 2076 patients were ultimately identified.The result of meta-analyses showed that the total effective rate of interferon group was higher than that of control group〔RR = 6.04,95% CI（4.36,8.37）,P 〈 0.00001〕.Fever of interferon group was of shorter duration than in control group〔MD =-1.30,95% CI（-1.80,-0.80）,P 〈 0.00001〕.Herpes pharyngis became extinct sooner in interferon group than in control group〔MD =-1.77,95% CI（-2.19,-1.36）,P 〈 0.00001 〕,and there was significant difference.Conclusion Aerosolized interferon combined with conventional treatment for pediatric herpangina is effective and safe.Howerver,due to the small number and low quality of included studies,larger sample-size and high-quality RCTs are needed.