GC法测定伤湿止痛膏中樟脑冰片薄荷脑水杨酸甲酯的含量

Determination of Camphor Menthol Synthetic Borneol and Methyl Salicylate in Shangshizhitong Adhesive Plaster by GC

目的用GC法同时测定伤湿止痛膏中樟脑、薄荷脑、冰片和水杨酸甲酯的含量。方法采用DB-FFAP毛细管柱;FID检测器;载气:氮气;柱温:125℃。结果樟脑、薄荷脑、冰片(异龙脑和龙脑)、水杨酸甲酯与其他色谱峰得到良好的分离,平均回收率分别为100.90%、98.40%、96.14%、97.14%;RSD分别为1.97%、1.77%、1.98%、1.47%。结论本法简单、准确、重复性好,可用于控制该产品的质量。

Objective To establish a method for determination of camphor,menthol,synthetic borneol and methyl salicylate in Shangshizhitong adhesive plaster.Methods The gas chromatography systern consisted of a DBFFAP capillary column,with FID as the detector and nitrogen as the carrier gas and at the column temperature of125 ℃.Results Camphor,menthol,synthetic borneol and methyl salicylate were well separated under the chromatographic condition.The average recovery was 100.90%（RSD = 1.97%） for camphor,98.40%（RSD = 1.77%） for menthol,96.14%（RSD = 1.98%） for synthetic borneol,and 97.14%（RSD = 1.47%） for methyl salicylate.Conclusion This methood is simple,accurate and reproducible for quality control of the preparation.