瞬时受体电位离子通道蛋白A1在支气管哮喘中的研究进展
摘要
瞬时受体电位离子通道蛋白A1(Transient receptor potential A1,TRPA1)是近年来研究比较多的与支气管哮喘发病相关的瞬时受体电位离子通道蛋白。国外研究证实了哮喘动物或患者体内的TRPA1表达量上调,用TRPA1受体拮抗剂可抑制哮喘的发生。虽许多实验仅局限于动物实验研究,但探讨TRPA1与哮喘的关系及其在哮喘发病机制中的具体作用对哮喘的治疗具有重大意义。本文就TRPA1的结构、分布特点及其在哮喘病理生理方面的作用研究进行综述。
出处
《广东医学院学报》
2014年第6期885-887,共3页
Journal of Guangdong Medical College
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