佛山地区散发性戊型肝炎的流行特征研究

Study on Epidemiological Characteristics of Sporadic Hepatitis E in Foshan Area

目的研究佛山地区散发性急性戊型肝炎的流行病学特征,为制定佛山地区预防控制措施提供依据。方法回顾分析87例散发性戊型肝炎患者的流行病学资料、临床特点、实验室检查及预后。结果戊型肝炎全年散发,以第二季度为高发,占30.8%%;中青年患者占71.3%;单纯抗-HEV-Ig M阳性者25例(26.7%),单纯抗-HEV-Ig G阳性29例(33.3%),两者同时阳性33例(37.9%);甲戊型肝炎病毒重叠感染1例,乙戊型肝炎病毒重叠感染1例。结论散发性戊型肝炎预后较好,乙、戊型肝炎病毒重叠感染及老年患者肝功能损害严重。

Objective： To study the epidemiological characteristics of Foshan sporadic acute Hepatitis E, for developing the control and prevention measures in Foshan area. Methods： Retrospective analysis on the epidemiology, clinical characteristics, the laboratory examination and the prognosis of 87 patients with sporadic Hepatitis E were conducted. Results： The sporadic hepatitis E occurs all the year through, particularly higher in the second quarter, accounting for 30.8%%; young patients accounted for 71.3%; 25 patients were simply positive in anti HEV- IgM （26.7%）, 29 patients were simply positive in anti HEV-IgG （33.3%）, while 33 patients were positive in both （37.9%）; one hepatitis E patient was superinfected by hepatitis A virus, while another hepatitis E patient was superinfected by hepatitis B virus. Conclusion： The prognosis of sporadic hepatitis E was more favorable, while those hepatitis B patients with hepatitis E superinfection and elderly patients suffered from severe liver injury.