血液灌流联合血液透析滤过抢救重度有机磷中毒的临床疗效探析

Clinical analysis of Hemoperfusion and Hemodiafiltration Combined Therapy on Rescuing Severe Rrganophosphorus Poisoning

目的:探讨血液灌流与血液透析滤过联合抢救重度有机磷农药中毒的临床效果。方法:选择怀集县人民医院2011年1月-2014年1月之间收治的100例急性重度有机磷农药中毒患者为观察对象,随机将其分为对照组和观察组,每组50例。对照组接受血液透析治疗,观察组接受血液灌流与血液透析滤过联合治疗,回顾分析两组患者疗效。结果:观察组在住院时间、中间综合征、阿托品用量等观察指标以及总有效率等方面均明显优于对照组,差异有统计学意义(P<0.05)。结论:血液灌流联合血液透析滤过治疗急性重度有机磷中毒具有较为理想的临床效果。

Objective To investigate the clinical effect of hemoperfusion and hemodiafiltration combined therapy on rescuing severe organophosphorus pesticide poisoning. Methods 100 cases of acute severe organophosphorus pesticide poisoning patients between January,2011 and January,2014 in our hospital were selected as the observed object, and randomly divided into the control group and the experimental group. The control group received hemodialysis treatment, while the experimental group received hemoperfusion and hemodiafiltration combined therapy, a retrospective analysis of patients within the two groups. Results The experimental group was significantly better than the control group on the clinical therapeutic targets, hospitalization time, intermediate syndrome, the dosage of atropine observation index and total effective rate （P 〈 0.05）. Conclusion Hemoperfusion and hemodiafiltration combined therapy has an ideal clinical effect on rescuing acute severe organophosphorus poisoning patients. It deserves a higher value to be applied.