摘要
乳腺癌细胞(MCF-7/ADM)的多药耐药性(MDR)是导致抗肿瘤药物临床化疗失败的主要原因。现认为细胞中的P-gp、Bcl-2、GST-π、TopoⅡ等蛋白可能与乳腺癌的多药耐药相关。近年来研究发现,不少中药能够下调MDR1 mRNA和/或P-gp的表达,从而逆转MCF-7/ADM细胞对抗肿瘤药物的多药耐药性,提高耐药细胞对化疗药物敏感性。主要对MCF-7/ADM细胞的多药耐药机制及有逆转MCF-7/ADM多药耐药作用的中药进行了综述。
Chemotherapy failure of antitumor drugs in clinical was mainly caused by multidrug resistance （MDR） of breast cancer cells （MCF-7/ADM）. P-gp,Bcl-2,GST-π,Topo Ⅱ and other proteins may be associated with the multi-drug resistance of breast cancer. In recent years, many traditional Chinese medicine were found that they can reduce the expression of MDR1 mRNA and/or P-gp protein, thereby reversing the multi-drug resistance of tumor drugs against human breast cancer cells and increase their chemosensitivity to chemotherapeutic drugs. Therefore, the summary is about resistance mechanisms of MCF-7/ADM and traditional Chinese medicines which can reverse multi-drug resistance of breast cancer ceils.
出处
《天津中医药》
CAS
2015年第4期253-256,共4页
Tianjin Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81001633
81173523
81303182)
天津市自然基金项目(13JCZDJC28600)
关键词
中药
MCF-7/ADM
多药耐药
P-GP
traditional Chinese medicine
MCF-7/ADM cell
muhidrug resistance
P-gp
