1341株铜绿假单胞菌的分布及其耐药性分析

Analysis of Clinical Distribution and Resistance of 1341 Strains of P.aeruginosa

目的:分析住院患者铜绿假单胞菌分离株的临床分布及耐药性特点。方法:选取2011年1月—2013年12月间从住院患者中各类标本,采用Vitek-32全自动微生物分析仪鉴定和药敏试验,并用WHONET 5.4版软件对药敏结果做统计分析。结果:3年度分离出铜绿假单胞菌1 341株,其主要来源于痰、尿液、咽拭子等标本,对头孢唑啉、头孢噻肟、氨苄西林及头孢呋辛钠的耐药率大于50%,对阿米卡星、庆大霉素、亚胺培南和美洛培南有较好的敏感性,但耐药率呈逐年上升趋势。结论:铜绿假单胞菌的检出率呈逐年上升趋势且多为多重耐药,临床应注意铜绿假单胞菌耐药性的监测。

Objective：To analyze the Clinical distribution and resistance characteristics of Paeruginosa strains iso- lated from inpatients. Methods： All kinds of specimens from January 2011 to December 2013 hospitalized patients wcre selected. Using Vitek-32 automatic analyzer identification and drug susceptibility test, and WHONET 5.4 software the drug susceptibility was statistically analysed. Results： During the 3 years, isolated I 341 strains of Paeruginosa, mainly came from sputum, urine, pharyngeal swab, etc.. Drug resistance rate was greater than 50% in cefazolin, cefotaxime, ampicillin and cefuroxime sodium. It had a good sensitivity to amikacin, gentamicin, imipenem and meropenem. There is a trend of increasing year by year. Conclusion： There is an increasing trend of isolated Paeruginosa strains. Paeruginosa strains are mainly multidrug resistant. Paeruginosa should be paid attention to clinical drug resistance monitoring.