中西医结合治疗血管迷走性晕厥临床研究

Clinical Analysis of Chaihushugansan Additional Prescription Combine with Metoprolol in Treating Vasovagal Syncope

目的:观察柴胡疏肝散加味方联合美托洛尔治疗血管迷走神经性晕厥(vasovagal syncope,VVS))的临床疗效。方法:选取经直立倾斜试验(flit table test,TTT)检查明确诊断为血管迷走性晕厥的患者132例,随机分成对照组和观察组,两组均口服美托洛尔,观察组根据患者证型联合服用柴胡疏肝散加味方,治疗后观察患者晕厥再发情况,评价其有效率及干预前后血流动力学变化。结果:观察组治疗后倾斜试验阳性率及抑郁量化评分明显低于对照组(P<0.05);随访6个月,观察组预防晕厥及晕厥先兆复发的有效率明显高于对照组(P<0.05);观察组干预后心率及血压减小明显高于对照组(P<0.05)。结论:美托洛尔是治疗VVS的基础用药,联合柴胡疏肝散加味方能增加其干预效果,柴胡疏肝散加味方联合美托洛尔治疗血管迷走性晕厥疗程短,疗效确切。

Objective：To investigate the clinical effect of Chaihushugansan Additional prescription combine with metoprolol in the treat- ment of vasovagal syncope. Methods：. Selected by upright tilt test examination diagnosis of vasovagal syncope patients 132 cases were randomly divided into control group and observation group. Two groups were given oral metoprolol. The observation group was additional given Chaihushugansan. After the treatment, observed syncope recurrence to evaluate of the total effective rate and hemodynamic changes before and after intervention. Results：After the treatment, the positive rate of inclining test and the score of depression quantitative in the observation group are inferior to the control group （P 〈 0.05 ）. In the observation group, the prevention of syncope and total effective rate of recurrent syncope precursor was obviously higher than that of control group（ P 〈 O. 05 ） after the follow-up visit of 6 months. The decrease of heart rate and blood pressure after the intervention in the observation group was obviously higher than that of control group （ P 〈 0.05 ）. Conclusion ： Metoprolol is basic drugs for the treatment of VVS, Chaihushugansan Additional prescription can increase its intervention effect. Chaihushugansan Additional prescription combine with metoprolol in the treatment of vasovagal syncope is short course and the curative effect is obvious.