舒血宁注射液与疏血通注射液治疗急性缺血性脑卒中的有效性及安全性对比研究

Study on effect and safety of treatment of acute ischemic stroke compared Shuxuening with Shuxuetong by intravenous infusion

目的比较舒血宁注射液与疏血通注射液治疗急性缺血性脑卒中的疗效和安全性,以期提高临床诊治水平。方法选取2012-05—2013-05 110例急性缺血性脑卒中患者为研究对象,分成2组,分别予舒血宁注射液与疏血通注射液治疗,观察临床效果和安全性。结果 2组治疗前和治疗1、2周后在收缩压、舒张压、心率、体温上比较差异无统计学意义(P均>0.05);NIH-NINDS评分上,2组治疗14d在椎基底动脉梗死评分、空腹血糖患者评分比较舒血宁注射液优于疏血通注射液(P<0.05),在颈内动脉系统梗死评分上比较差异无统计学意义(P>0.05),在高同型半胱氨酸评分上疏血通注射液优于舒血宁注射液(P<0.05)。结论对急性缺血性脑卒中治疗,要结合梗死部位、血糖和血同型半胱氨酸选择何种药物。

Objective To investigate effect and safety of treatment of acute ischemic stroke compared Shuxuening with Shuxuetong by intravenous infusion in order to improve the clinical diagnosis and treatment.Methods 110 patients with acute ischemic stroke patients selected for the study from May 2012 to May 2013 were divided into two groups ,which were respec-tively given therapy of Shuxuening and Shuxueotong by intravenous infusion. Clinical effects and safety between two groups were observed before and after treatment.Results Before treatment and after treatment at first and second week in two groups , the differences of systolic blood pressure ,diastolic blood pressure ,heart rate ,and temperature all had no statistical significance （P〉0.05）. In NIH-NINDS scores ,the scores of vertebral basilar artery infarction and fasting plasma glucose in 14-day treat-ment in Shuxuening group were significant prior to that in Shuxuetong group （P〈0.05） ,while the difference in internal carot-id infarction was not statistically significant （P〉0.05）. The scores of high homocystein in Shuxuetong group were better than that in Shuxuening group （P〈 0.05）.Conclusion For acute ischemic stroke ,selecting Shuxuening or Shuxuetong therapy should be based on plasma glucose ,blood homocysteine and infarction location.