缺血性脑卒中病因学分型与血浆同型半胱氨酸水平的关系

Analysis of the relationship between etiological type and plasma homocysteine levels of ischemic stroke

目的研究缺血性脑卒中病因学分型与血浆同型半胱氨酸水平的关系。方法参照TOAST分型标准将2011-08—2013-12我院收治的大动脉粥样硬化型脑卒中(LAA)、小动脉闭塞型脑卒中(SAO)、心源性脑卒中(CE)、其他少见病因型脑卒中(SOE)、不明原因型脑卒中(SUE)患者纳入观察组,将同期在我院接受体检的50例健康者纳入对照组,比较2组患者血清同型半胱氨酸的水平及异常例数。结果 (1)观察组患者的血清同型半胱氨酸水平高于对照组;(2)LAA组的同型半胱氨酸水平及同型半胱氨酸异常例数高于其余4组,差异有统计学意义(P<0.05);且SAO组、CE组、SOE组、SUE组之间同型半胱氨酸水平及同型半胱氨酸异常例数无显著差异。结论缺血性脑卒中患者的血浆同型半胱氨酸水平异常升高,且以大动脉粥样硬化型脑卒中患者的升高最为明显。

Objective To study the relationship between etiological type and plasma homocysteine levels of ischemic stroke.Methods Patients with large artery atherosclerotic stroke （LAA） ,small artery occlusion stroke （SAO） ,cardiogenic stroke （CE） ,other rare-caused stroke （SOE） and unexplained stroke（SUE） in our hospital from August 2011 to December 2013 were enrolled in observation group according to classification standard of TOAST ,and healthy persons receiving physical examination in our hospital consisted of control group. Then serum homocysteine levels were compared and abnormal cases were recorded.Results （1） Serum homocysteine levels of observation group were higher than those of control group;（2）Ho-mocysteine levels and homocysteine abnormal cases of LAA group were higher than those of other four groups ,the differences had statistical significances（P〈0.05）;homocysteine levels and homocysteine abnormal cases in SAO group ,CE group ,SOE group ,SUE group all had no differences（P〉 0.05）.Conclusion Plasma homocysteine levels rise in patients with ischemic stroke and the increase is most obvious in patients with large artery atherosclerotic stroke.