地塞米松与甘露醇对急性重症脑血管病脑保护作用观察

Observation on dexamethasone combined with mannitol for brain protection of patients with acute severe cerebrovascular disease

目的分析使用地塞米松与甘露醇对急性重症脑血管病患者的脑保护作用,为提高患者的治疗效果提供参考。方法选择2011-08—2014-03我院收治的急性重症脑血管病患者60例为研究对象,随机分为2组。对照组使用甘露醇联合常规治疗,实验组给予常规治疗、甘露醇联合地塞米松治疗,观察2组治疗效果。结果实验组患者病死率更低,GCS评分优,与对照组患者比较差异有统计学意义(P<0.05);2组并发症对比差异无统计学意义(P>0.05)。结论地塞米松联合甘露醇对急性重症脑血管病患者的治疗效果更好,脑保护作用强,且安全性好。

Objective To analyze and research the brain protection of dexamethasone combined with mannitol for patients with acute severe cerebrovascular disease, for providing reference for improving the treatment effect of patients. Methods 60 patients with acute severe cerebrovaseular disease treated in our hospital from August 2011 to March 2014 were selected as clin ical research objects and were divided into two groups randomly. The control group was treated with the conventional treatment of mannitol combination, and the experiment group received the conventional treatment, dexamethasone combined with mannitol. The treatment effect of two groups was compared. Results The death rate of the experiment group was lower, and GCS score was better, which had evident difference from the control group, P〈0.05. The difference for the complications of the experiment group and the control group was not evident, P〉0.05. Conclusion Dexamethasone combined wilh mannitol has better effect for patients with acute severe cerebrovascular disease, with great brain protection and good safety.