尤瑞克林对急性脑梗死患者神经功能缺损的恢复作用及安全性

Effect of urinary kallidinogenase on the improvement of symptoms of nerve function defect in acute cerebral infarction and its safety

目的观察尤瑞克林治疗急性脑梗死的疗效和安全性。方法 160例急性脑梗死患者随机分为治疗组和对照组,2组均给予抗血小板聚集、调脂、控制血压、血糖等常规治疗。治疗组另加用尤瑞克林0.15PNAU加入0.9%氯化钠注射液100mL静滴,1次/d,使用14d。治疗前、治疗后14d分别进行美国国立卫生研究院卒中量表评分、日常生活活动能力量表评分。结果 2组治疗前、治疗后14dNIHSS和ADL评分组内比较及组间比较均有显著差异(P<0.05),2组均未见出现明显不良反应。结论尤瑞克林可促进急性脑梗死患者神经功能缺损症状的恢复,降低致残率,不良反应少。

Objective To observe the clinical effect and safety of urinary kallidinogenase in treatment of acute cerebral in‐farction. Methods One hundred and sixty patients with acute cerebral infarction were randomly divided into 2 groups;each pa‐tient was given the treatment of anti‐platelet aggregation ,lipid‐loweringing ,controling of blood pressure ,blood sugar and symp‐tomatic treatment. The treatment group was extra given urinary kallidinogenase 0.15 PNAU with 100 mL NS intravenous dripped once a day for 14 days. The NIHSS scores and ADL degree were marked before the treatment as well as the 14th day after the treatment. Results The statistical analysis of the NIHSS scores and ADL degree before the treatment and the 14th day after the treatment showed significant differences（P〈0.05）. The ADRs was none seen in both two groups. Conclusion Urinary kallidinogenase could improve the symptom of acute cerebral infarction ,and reduce the rate of disability ,with less ad‐ verse reaction.