西北地区健康人群三酰甘油参考区间的初步探讨

Study on reference intervals of triglyceride for healthy population in northwest area of China

目的建立西北地区健康人群血清三酰甘油（TG）的参考区间。方法参照国际临床化学和实验室医学联盟（IFCC）多中心酶学研究参考人群筛选标准,募集18∽79岁健康参考人群1 098例,其中男506例、女592例,分别用和光试剂检测系统和罗氏试剂检测系统建立西安地区健康人群TG的参考区间。结果两个系统间检测结果的差异无统计学意义（P〉0.05）。农村与城市人群检测结果差异无统计学意义（P〉0.05）。各年龄段间,18∽〈30岁与30∽〈40岁两组检测结果间差异有统计学意义（P〈0.05）;30∽〈40岁与40∽〈50岁两组检测结果间差异有统计学意义（P〈0.05）;40∽〈50岁与50∽〈60岁两组检测结果间差异有统计学意义（P〈0.05）;50∽〈60岁与60∽79岁两组检测结果间差异无统计学意义（P〉0.05）。各年龄段间男性和女性结果有差异。18∽〈30岁：0.42∽2.06mmol/L（男）,0.33∽1.61mmol/L（女）;30∽〈40岁：0.44∽2.15mmol/L（男）,0.43∽1.96mmol/L（女）;40∽〈50岁：0.53∽2.21mmol/L（男）,0.48∽2.14mmol/L（女）;50∽79岁：0.58∽2.30mmol/L（男）,0.51∽2.23mmol/L（女）。结论西北地区健康人群TG检测结果在不同年龄段间检测结果存在明显差异,男性和女性检测结果差异较大。随着年龄的增长,TG的检测结果逐渐增大。本次研究表明,西北地区TG参考区间有所提高,本文试验结果高于目前临床所用的参考区间,高于中国血脂异常防治建议提出的合适水平,囊括了美国胆固醇教育计划-成人治疗指南（NCEP-ATPIII）文件中的合适水平和临界水平。

Objective To establish the reference intervals of triglyceride（TG） for the healthy population in the northwest area Of China. Methods Referring to the reference population screening criteria for multi-center enzymology study by the International Federation of Clinical Chemistry （IFCC）, 1 098 healthy individuals aged 18-79 years were recruited, including 506 males and 592 fe- males. The reference intervals of TG for the healthy population in Xi＇an area were established by the Roche reagent detection system and the Wako reagent detection system. Results The differences in the test results between the two systems had no statistical significance （P〈0.05）. The test results had no statistical differences between rural and urban populations （P〉0.05）. The test re- sults had statistically significant differences between the 18--〈30 years old group and the 30--%40 years old group（P〈0.05） ,be- tween the 30--〈40 years old group and the 40--〈50 years old group（P〈0.05） and between the 40--〈50 years old group and the 50--〈 60 years old group（P〈0.05）,but the test results had no statistical difference between the 50--〈60 years old group and 60--79 years old group（P〉0.05）. The test results had statistically significantly differences in each age group between males and females. Therefore, the gender-specific reference intervals of TG were established as 18--%30 years old：0.42--2.06 mmol/L （male） ,0.33--1.61 mmol/L（female） ;30--〈40 years old：0.44--2.15 mmol/L（male） ,0.43-- 1.96 mmol/L（female） 〈40--%50 years old：0.53--2.21 mmol/L（male） ,0.48--2.14 mmol/L（female） ;50--79 years old：0.58--2.30 mmol/L（male） ,0.51--2.23 mmol/L（female）. Conclusion The test results of TG have significant differences among different age groups and the test results have large difference between male and female too. The test results of TG are gradually increased with age. This study shows that the reference intervals of TG for the healthy population in the northwest area of China is somewhat increased. The test results in this study is higher than the clinically used reference intervals of TG and the appropriate level recommended by the China＇s Guidelines for Control of Blood Lipids Disorders,which encompasses the appropriate level and critical level of NCEP-ATPIII file.