银杏达莫注射液联合低分子肝素钙治疗慢性肺心病急性加重期对棘形红细胞计数和红细胞体积变化的影响

Influence of Ginkgo dipyridolum injection combined with low molecular weight heparin sodium for treating acute exacerbation of chronic cor pulmonale on thorn RBC count and RBC volume change

目的观察银杏达莫注射液联合低分子肝素钙对慢性肺源性心脏病(CPHD)急性加重期棘形红细胞计数和红细胞体积分布宽度(RDW)变化的影响。方法选取88例临床确诊CPHD急性加重期患者,分为常规治疗组(B组,n=44)和常规治疗+银杏达莫注射液和低分子肝素钙联合治疗组(C组,n=44);同时选择健康体检者作为对照组(A组,n=50)。比较三组棘形红细胞计数及RDW。结果 C组患者经常规治疗+银杏达莫注射液和低分子肝素钙治疗后,临床总有效率为90.9%,明显优于B组的61.4%,差异有统计学意义(P<0.05)。治疗前,B、C两组患者棘形红细胞计数及RDW明显高于A组(P<0.05);治疗后,B组RDW较治疗前明显降低(P<0.05),C组棘形红细胞计数及RDW均较治疗前明显降低(P<0.05);与B组治疗后比较,C组治疗后棘形红细胞计数及RDW降低明显(P<0.05)。结论常规治疗+银杏达莫注射液和低分子肝素钙联合治疗CPHD急性加重期患者临床效果较单独常治疗好,治疗后棘形红细胞计数及RDW较后者明显降低(P<0.05)。

Objective To investigate the influence of Ginkgo dipyridolum injection combined with low molecular weight heparin calcium on thorn red blood celI（RBC） count and the change of RBC volume distribution width （RDW） in the patients with acute ex- acerbation of chronic pulmonary heart disease（CPHD）. Methods The selected 88 cases of clinically diagnosed acute exacerbation of CPH/） were divided into the conventional treatment group（group B, n = 44） and the conventional treatment plus Ginkgo dipyri- dolum injection and low molecular weight heparin calcium combined treatment group（group C,n= 44） ;at the same time the individ uals of healthy physical examination during the same period were selected as the control （group A, n=50）. Then the thorn RBC count and the RDW change were compared among 3 groups. Results The clinical total effective rate after treatment in the group C was 90.9%, which was significantly higher than 61.4% in the group B,difference was statistically significant（P〈0.05）. The thorn RBC count and RDW before treatment in the group B and C were significantly higher than those in the group A with statistical difference （P〈0.05） ;RDW after treatment in the group B was obviously decreased compared with before treatment（P-〈0.05）, the thorn RBC count and RDW after treatment in the group C were significantly decreased than before treatment （P〈0.05） ;compared with the group ]3 after treatment,the thorn RBC count and RDW after treatment in the group C were significantly decreased （P〈 0.05）. Conclusion Conventional treatment plus Ginkgo dipyridolum injection and low molecular heparin calcium has a better clinical effect in treating acute exacerbation of CPHD than the single conventional therapy, the thorn RBC count and RDW after treatment are significantly decreased compared with the latter（P〈0.05）.