摘要
目的:观察健脾解毒方调节老年肺癌免疫功能的临床疗效。方法:将61例肺癌患者随机分为2组,中药联合化疗组32例,单纯接受化疗的对照组29例,两组均同时配合支持治疗,治疗8周后,进行临床疗效观察;采用流式细胞技术(FACS)检测治疗前后外周血T淋巴细胞亚群、NK细胞和CD4+CD25+Treg细胞变化、临床疗效、不良反应发生情况。结果:两组在肺癌近期有效率和改善化疗后骨髓抑制方面无显著性差异(P>0.05),但中药组在中医症状改善和提高生活质量方面优于对照组(P<0.05);在肺癌近期稳定率(CR+PR+NC/N)方面,中药组优于对照组(P<0.05);中药组治疗后T细胞(CD3)和NK细胞明显增加,CD8细胞降低(P<0.05);两组治疗CD4+CD25+Treg细胞占CD4+比重有降低,观察组比值低于对照组,具有显著性差异(P<0.05)。结论:临床研究表明,健脾解毒方在一定程度上可以改善患者细胞免疫功能,改善肺癌临床症状,提高肺癌近期稳定率。
Objective: To observe the effect on lung cancer related symptoms of TCM Recipe plus chemotherapy treatment of patients wish advanced Lung cancer. Methods : 62 patients with advanced Lung cancer were randomized divided into 2 groups : chemotherapy and TCM and chemotherapy group, short term effect, survival, to xicity, improvement of symptoms were evaluated after at 8 weeks of treatment. Results :clinical study, there no significant differences between groups 2 response rates and hematological toxicity ( P〉0.05 ) .observe group had symptomatic improvement, significantly better than control group ( P〈0.05 ). Stabilizing rates ( CR+PR+NC/N ), observe group much better then control group, T cells after treatment observation group ( CD3 ) and NK cells were significantly increased, CD8 cells decreased ( P〈0.05 ) .Two groups CD4^+CD25^+Treg cells in CD4^+propornion has decreased, the ratio of the observation group than the control group, with significant difference ( P〈0.05 ). Conclusion : Clinical studies show that the prescription can be significantly improved patients with cellular immune function, improve symptoms of lung cancer, improve lung cancer rates stable.
出处
《辽宁中医药大学学报》
CAS
2015年第5期150-153,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
嘉定区中医院第一批中医临床重点(培育)专科建设资助项目(2012-ZD02)
关键词
肺癌
健脾解毒方
免疫功能
lung cancer
Jianpi Jiedu decoction
prescription