肌球蛋白磷酸化的研究进展

Progresses on Myosin Phosphorylation

肌球蛋白是肌原纤维粗丝的组成单位,由多条重链与多条轻链组成,被视为一种分子马达。在肌肉收缩、趋化性胞质分裂、胞引作用、膜泡运输以及信号传导等生理过程中起重要作用。目前肌球蛋白磷酸化是研究的一个热点,它对细胞的迁移、收缩、胞质分裂以及其他未知功能都有着至关重要的作用。肌球蛋白磷酸化分为重链的磷酸化与轻链的磷酸化。根据国内外的最新相关研究报道,分别从肌球蛋白的结构与功能、磷酸化的作用机制、磷酸化的生物学功能以及最新研究成果等方面,对肌球蛋白的磷酸化研究进展进行阐述。

Myosin is the unit of myofibril raw silk, composed of multiple heavy chains and light chains, is regarded as a kind of molecular motors. It mainly works on muscle contraction, chemotaxis cytoplansmic di- vision, cell function, vesicular transport and signal transduction. Recently myosin phosphorylation is a hot topic, as it plays an important role in cell migration, contraction, cytokinesis and other unknown functions. Myosin phosphorylation is divided into heavy chain and light chain phosphorylation. According to the latest reports, it mainly elaborates the research progress on the phosphorylation of myosin on the structures and functions, the action mechanism of phosphorylation, the biological function of phosphorylation and the latest research results.