枳实、白术组方中药制剂治疗慢性便秘文献分析

Clinical Research on Chronic Constipation Treated with Chinese Materia Medica Preparation Composed by Zhishi( Fructus Aurantii Immaturus) and Baizhu( Rhizoma Atractylodis Macrocephalae)

目的:评价枳实、白术组方中药制剂治疗慢性便秘的有效性及安全性。方法:计算机检索中国生物医学文献服务系统、维普中文科技期刊全文数据库、万方数据资源、中国知网全文数据库,检索时间从建库到2013年9月。检索词包括便秘、传输、推动力、枳术、枳实白术。结果:检索到相关文献67篇,最终纳入10篇文献[9-18],包括1382例患者。其中1篇为CCT[10],其余均为RCTs,10篇均为中文文献,枳实、白术制剂痊愈率、总体有效率均优于对照组,复发率低于对照组,未发现明显不良反应。结论:枳实、白术组方中药制剂治疗慢性便秘安全有效,但缺乏高质量研究。

Objective： To evaluate the efficacy and safety of Chinese Materia Medica Preparation Composed by Zhishi （ Fructus Au- rantii Immaturus） and Baizhu （ Rhizoma Atractylodis Macrocephalae） for the treatment of chronic constipation. Methods ： The datebases of SinoMed, Chinese science and technology periodicals database, Wanfang data resource, CNKI were retrieved. The re- trieval time is from the creation of database to September of 2013. The search terms include ： constipation, transportation, motives, Zhishi （Fructus Aurantii Immaturus） , and Baizhu （Rhizoma Atractylodis Macrocephalae）. Results ：67 related periodicals were re- trieved and finally 10 of them （all were Chinese literature） got included,which include 1382 cases of patients. 1 periodical was CCT and the rest were RCTS. Compared with the control group, general effective rate and healing rate of treatment group were sig- nificantly better and recurrence rate was lower in the treatment group when compared with these in control group. No obvious ad- verse reaction was found. Conelusion：Zhishi （Fructus Aurantii Immaturus）, and Baizhu （ Rhizoma Atractylodis Maeroeephalae are safe and effective in the treatment of chronic constipation. However, relative studies of high quality are lacking.