蛭龙活血通瘀胶囊对缺血性脑卒中患者急性期脑水肿及hs-CRP的影响

Study of changes on cerebral edema and hs-CRP in cerebral ischemic stroke patient treated by Zhilonghuoxuetongyu capsule

目的:通过蛭龙活血通瘀胶囊对缺血性脑卒中患者急性期脑水肿及hs-CRP含量变化影响的观察,验证其对缺血性脑卒中急性期的脑保护作用。方法:72例缺血性脑卒中患者,随机分为对照组(常规治疗)和治疗组(常规治疗加蛭龙活血通瘀胶囊)。对治疗前后神经功能缺损(ESS)、日常生活能力(ADL)评分和脑水肿、hs-CRP含量动态变化进行分析。结果:两组经药物治疗后,ESS、ADL比较有统计学意义(P<0.05或P<0.01);患侧CEI扰动系数值与hs-CRP均在第3 d开始升高,第5 d达到高峰,且呈正相关关系,治疗组明显低于观察组(P<0.05或P<0.01)。结论:蛭龙活血通瘀胶囊对缺血性脑卒中急性期有脑保护作用,且hs-CRP可能参与脑水肿的发生、发展过程,为临床早期检测提供新的指标。

Objective： Through observing the changes of cerebral edema and hs-CRP in cerebral ischemic stroke patient treated by Zhilonghuoxuetongyu capsule, try to verify the medicine＇s protective effect against acute cerebral ischemic stroke. Methods： 72 patients with acute cerebral ischemia were randomly divided into control group （conventional therapy group）, treatment group （conventional therapy plus Zhilonghuoxuetongyu capsule therapy group）. Their neurologic impairment （ESS）, activity of daily living （ADL）, cerebral edema, and C reactive protein （CRP） level were compared before and after treatment. Results： ESS and ADL had statistical significance between two groups （P〈0.05 or P〈0.01）CEI and hs-CRP started to increase from the 3rd day, peaked at the 5th day, and there was a positive correlation between the two data, treatment group was significantly lower than control group （P〈0.05 or P〈0.01）. Conclusion：Zhilonghuoxuetongyu capsule can protect the brain from acute cerebral ischemic stroke,and hs-CRP may be involved in the development of cerebral edema, which may provide a new indicator for early clinical detection.