不同剂量氢氯噻嗪对长期服药患者血尿酸及电解质的影响

Effects of different doses of hydrochlorothiazide on long- term medication patients with blood uric acid and electrolyte

目的:研究不同剂量氢氯噻嗪对长期服药者血尿酸及电解质的影响。方法:将98例长期服用氢氯噻嗪的患者随机分为小剂量组(12.5 mg,每日2次)49例和中大剂量组(25 mg,每日2次)49例,服药8周后随访血尿酸及电解质。结果:小剂量组血尿酸升高明显低于中大剂量组(P<0.05),血钾、钠、氯降低明显低于中大剂量组(P<0.05)。结论:长期使用小剂量较大剂量氢氯噻嗪的安全性更好。

Objective：To study the effects of different doses of hydrochlorothiazide on serum uric acid and electrolyte of the patients who long - term take hydrochlorothiazide. Methods：Nighty - eight cases of long - term taking hydrochlorothiazide were randomly divided into low dosage group（49 cases,12. 5 mg,bid）and high dose group（49 cases,25 mg,bid）,8 weeks af-ter treatment follow - up of blood uric acid and electrolyte. Results：Serum uric acidi of low dose group was significantly lower than that in high dose group（P 〈 0. 05）,serum potassium,sodium,chlorine was significantly lower than in the high dose group （P 〈 0. 05）. Conclusion：Long term use of low dose hydrochlorothiazide is safer than using high doses of it.