从“阴中求阳”角度探讨右归丸治疗肾阳虚证的临床疗效

Clinical Observation of Yougui Pills in Treating Kidney-yang Deficiency Syndrome Based on Theory of Generating Yang by Activating Yin

【目的】观察右归丸及其拆方治疗肾阳虚证的临床疗效。【方法】采用随机对照方法,将60例肾阳虚证患者随机分为右归丸治疗组及其拆方温肾阳对照组各30例。治疗组给予右归丸治疗,对照组给予右归丸中的温肾阳中药复方治疗,2组均以4周为1个疗程,连续用药2个疗程,观察2组临床疗效,以及治疗前后症状积分和外周血白细胞、血清抗体、补体等指标的变化情况。【结果】在临床疗效及症状积分、外周血白细胞的改善方面,治疗组均优于对照组(P<0.05或P<0.01),在血清抗体、补体的改变方面2组作用差异无统计学意义(P>0.05)。【结论】右归丸治疗组在治疗肾阳虚证方面优于其单纯温肾阳中药复方对照组,提示"阴中求阳"法优于单纯温肾阳治疗。

Objective To observe the therapeutic effect of Yougui Pills and its separate formula for the treatment of kidney-yang deficiency syndrome. Methods A total of 60 patients of kidney-yang deficiency syndrome were randomly divided into treatment group and control group, 30 cases in each group. Treatment group was treated with Yougui Pills, and the control group was given the separate formula from Yougui Pills which had the actions of warming kidney yang. Four weeks constituted one treatment course and the treatment covered 2 courses. The changes of major clinical symptom scores, total effectives rate and associated indexes such as peripheral white blood cells, serum antibodies, and complements were compared between the two groups following the treatment for 8 weeks. Results The total effective rate, and improvement of major clinical symptoms and the peripheral white blood cells in the treatment group were superior to those in the control group （ P0.05） .Conclusion Yougui Pills show better effect than its kidney-yang-warming separate formula for the treatment of kidney-yang deficiency syndrome, indicating that the method of generating yang by activating yin is superior to the method of simply nourishing kidney yang.