电针足三里、关元穴对脓毒症患者炎症反应的影响

Effect of Zusanli and Guanyuan Electroacupuncture on Inflammatory Reaction in Sepsis Patients

【目的】观察电针足三里、关元穴对脓毒症患者炎症反应的影响。【方法】通过前瞻随机对照的方法,将58例脓毒症患者随机分为电针组与对照组各29例。对照组给予常规西医治疗,电针组在常规西医治疗的基础上联合电针足三里和关元穴。比较2组患者的重症监护室(ICU)住院时间,观察2组患者治疗前后血乳酸及白细胞计数(WBC)、中性粒细胞计数(Neut)、C反应蛋白(CRP)、血沉(ESR)、降钙素原(PCT)等炎症反应指标的变化情况。【结果】电针组患者入住ICU时间显著少于对照组,差异有统计学意义(P<0.05)。治疗后第7天,电针组的乳酸水平显著低于对照组,差异有统计学意义(P<0.05)。治疗后,电针组患者的各项炎症反应指标均较治疗前显著下降(P<0.05),且治疗后第7天电针组患者的各项炎症反应指标均显著低于对照组,差异有统计学意义(P<0.05)。【结论】电针足三里、关元穴可减轻脓毒症患者的炎症反应,从而达到提高脓毒症疗效的目的。

Objective To study the effect of Zusanli and Guanyuan electroacupuncture （ EA） on inflammatory reaction in patients with sepsis. Methods A prospective and randomized trial was carried out in 58 sepsis patients, and the patients were randomly divided into EA group and control group. Patients in both groups were given conventional western medicine treatment, and EA group received EA at acupoints of Zusanli and Guanyuan additionally. The hospitalization time in intensive care unit （ ICU） of the two groups was compared. The changes of serum lactic acid （LA） level and inflammatory indexes including white blood cell and neutrophil count, C- reactive protein （CRP）, erythrocyte sedimentation rate （ESR） and procalcitonin （PCT） of the two groups were observed before and after treatment. Results The hospitalization time in ICU of EA group was less than that of the control group, and the difference was statistically significant （ P〈0.05） . On the seventh day after treatment, the serum LA level of EA group was significantly lower than that of the control group （ P〈0.05） . Inflammatory indexes of EA group were decreased after treatment compared with those before treatment （ P〈0.05） , and on seventh day after treatment, the inflammatory indexes of EA group were significantly lower than those of the control group （ P〈0.05） . Conclusion EA at acupoints of Zusanli and Guanyuan is effective for the treatment of sepsis through reducing the inflammatory reaction of sepsis patients.