细丝蛋白与其蛋白配体的相互作用

Filamins and Their Protein Ligands

细丝蛋白是交联肌动蛋白丝的同源二聚蛋白,它由肌动蛋白结合蛋白结构域(ABD)和细丝蛋白类型的免疫球蛋白(Ig_FLMN)结构域组成(其中,盘基网柄菌细丝蛋白(ddFLN)有6个免疫球蛋白,人细丝蛋白有24个免疫球蛋白)。超过90种蛋白配体能与细丝蛋白相互作用,参与细胞迁移、粘附、扩散和信号转导,发挥细胞迁移和极化、凝聚、磷酸化、信号转导、蛋白水解、离子通道、免疫调节、膜受体、激素受体、细胞核功能的作用。至今,越来越多的畸形病变被发现与细丝蛋白的基因突变有关,这也说明细丝蛋白在生物发育过程中起了至关重要的作用。

Filamins are actin-filament-crosslinking homologous dimerization proteins. They are constituted by actin binding domain （ABD） and filamin-type immunoglobulin domains （Ig_FLMN）（for example,Dic- tyosteliumdiscoideum（ddFLN） has only six Ig_FLMN; whereas human filamins have twenty-four Ig_ FLMN domains in each monomer）. In recent years, filamins have been found to interact with more than 90 protein ligands and play important roles in cell motility, adhesion, spreading and signal transduction. Specifically, the roles of filamins have been scrutinized in the following areas such as cell mobility and po- larity, coagulation, phosphorylation signalling transduction, proteolysis, ion channels, immunoregulation, membrane receptors, hormone receptors, and nuclear function. Further, missense mutations of fil- amins have been discovered and assigned to human diseases. These discoveries have revealed that filamins play a vital role in biological development and are an important target for biomedical research.