STK15、P53蛋白在结肠癌中的表达及其临床意义

Expressions and clinical significance of STK15 and P53 in colon cancer

目的探讨结肠癌组织中丝氨酸/苏氨酸激酶15(Serine/threonine kinase15,STK15)、P53蛋白的表达及其临床意义。方法采用免疫组织化学法检测72例结肠癌组织和36例癌旁正常组织中STK15、P53蛋白的表达情况,分析两者在结肠癌发生发展中相关性,及与结肠癌患者临床病理特征之间的关系。结果 STK15、P53蛋白在结肠癌组织中的阳性表达率分别为65.3%(47/72)、69.4%(50/72),明显高于癌旁正常组织中的表达,两者在结肠癌的发生发展中比较差异有统计学意义(r=0.615,P<0.05)。STK15在结肠癌中表达与肿瘤TNM分期、浸润深度密切相关(P<0.05),与患者年龄、性别、肿瘤大小、分化状态无关(P>0.05)。结论 STK15、P53在结肠癌中高表达,且两者在结肠癌中呈正相关,提示STK15、P53可能共同参与了结肠癌发生发展的过程,二者的表达可能与结肠癌的不良预后有密切关系。

Objective To investigate expression and clinical significance of STK15 and P53 in colon cancer. Methods The immunohistochemieal method was used to determine the expressions of STK15 and P53 in the colon cancer tissues of 72 patients and adjacent normal tissues of 36 patients to explore the correlation of the two protein in colon carcinogenesis process, and analyze the relationship between these two proteins and pathological features of colon cancer. Results The expressions of STK15 （ 65.7%, 47/72） and P53 （ 69.4%, 50/72）, in colon cancer tissue were significantly higher than that in adjacent normal tissue （5.6%, 2.8% respectively） （P 〈0.001）,these proteins were positively correlated in colon adenocarcinoma （r=0.615, P 〈0.001 ）. The expression of these two kinds of protein were related with the TNM staging of tumor, depth of invasion （P 〈 0.05 ）, no association with patients age, gender, tumor size and histological grading was observed （P 〉0.05）. Conclusion STK15, p53 showed high expression in colon cancer, and a positive correlation between the two proteins, suggesting that STK15, p53 might be involved in the process of developing colon cancer. And the expression of the two proteins might be closely associated with poor prognosis in colon cancer treatment.