银杏达莫注射液治疗缺血性脑卒中患者的疗效观察

Observation on efficacy of ginkgo leaf extract and dipyridamole injection in treatment of ischemic stroke patients

目的评价银杏达莫注射液治疗缺血性脑卒中患者的临床疗效,为缺血性脑卒中患者的治疗提供病理生理依据。方法 60例缺血性脑卒中患者随机分为治疗组和对照组,每组30例,治疗组患者采用常规治疗联合银杏达莫注射液治疗,对照组仅采用常规治疗,疗程2周,观察治疗后两组的临床疗效及对血浆8-异前列腺素F2α(8-iso-PGF2α)的改善程度。结果治疗组治疗前后的血浆8-iso-PGF2α值为(506.82±46.21)pg/m L和(309.49±37.69)pg/m L,对照组治疗前后的血浆8-iso-PGF2α值为(501.37±48.32)pg/m L和(369.41±42.51)pg/m L,治疗后比较治疗组对血浆8-iso-PGF2α的效果优于对照组,差异有统计学意义(t=2.59,P<0.05)。治疗组在血压、血脂和神经功能缺损(NHISS)评分方面也优于对照组(t=2.34,P<0.05)。结论银杏达莫注射液有抗氧化应激作用,能促进缺血性脑卒中患者的功能恢复、减轻残障。

Objective To observe the therapeutic effects of ginkgo leaf extract and dipyridamole injection on ischemicstroke patients and discuss the pathophysiological mechanism. Methods Sixty ischemic stroke patients, randomly dividedinto the treatment group and control group each comprised 30 cases. The patients in treatment group were treated with ginkgoleaf extract and dipyridamole injection combined with routine treatment, the patients in control group were only treated withroutine therapy, the curative effect and changes of plasma 8- isoprostanes F2α improvement in the two groups were observedtwo weeks after treatment. Results The plasma 8-iso-PGF2α levels in the treatment group were（506.82 ＋ 46.21） pg/m L and（309.49 ＋ 37.69） pg/m L before and after treatment while the plasma 8-iso-PGF2α levels were（501.37 ＋ 48.32） pg/m L and（369.41 ＋ 42.51） pg/m L in the control group before and after treatment., the treatment group effect on plasma 8-iso-PGF2α isbetter than that of the control group（t =2.59,P〈0.05. The treatment group in blood pressure, blood lipid and neurologicaldeficit（NHISS） score is better than that of the control group showing significant difference（t =2.34,P〈0.05）. Conclusions Ginkgo leaf extract and dipyridamole injection possesses anti- oxidative stress effect, promote the functional recovery andreduce disability of ischemic stroke patients.