血清结核分枝杆菌IgG抗体检测对结核病的诊断价值

Value of detection of serum IgG antibody against Mycobacterium tuberculosis in diagnosis of tuberculosis

目的评价血清结核分枝杆菌(TB)-Ig G抗体检测对结核病的诊断价值。方法应用TB-Ig G试剂盒对确诊肺结核患者365例和非结核性呼吸系统疾病患者185例,共550例初诊疑似结核患者进行血清结核分枝杆菌Ig G抗体检测,同时进行痰涂片抗酸杆菌镜检和胸部X线片检查。结果确诊肺结核患者365例中检测出血清TB-Ig G抗体阳性285例,阴性80例;非结核性呼吸系统疾病185例中检测出血清TB-Ig G抗体阳性53例,阴性132例。血清TB-Ig G抗体检测诊断活动性肺结核的敏感性为78.08%(285/365);特异性为71.35%(132/185)。在365例活动性肺结核患者中,TB-Ig G抗体检测阳性检出率为78.08%,远高于痰涂片阳性检出率38.36%(140/365)(χ2=118.41,P<0.05),差异具有统计学意义。结论血清TB-Ig G抗体检测对诊断疑似结核患者有一定价值,是一种快速、简单、有较高敏感性和特异性的结核病辅助诊断方法。

Objective To assess the value of detection of serum Ig G antibody against Mycobacterium tuberculosis indiagnosis of tuberculosis. Methods Serum Ig G antibody against Mycobacterium tuberculosis in 550 initially suspectedtuberculosis cases comprising 365 confirmed tuberculosis cases and 185 non- tuberculosis respiratory system cases weredetected by TB-Ig G kit,detection of acid-fast bacilli in sputum slides and chest X-ray were also performed simultaneously.Results Two hundred and eighty-five out of 365 confirmed tuberculosis cases were positive for acid-fast bacillus and 80 were negative; 53 out of the 185 non-tuberculosis respiratory system cases were positive for acid-fast bacillus and 132 caseswere netagive. The sensitivity of detection of serum TB- Ig G antibody in diagnosis of active pulmonary tuberculosis was78.08%（285/365）; the specificity was 71.35%（132/185）, the positive rate in detection of TB-Ig G antibody was 78.08%, farhigher than the detection of sputum smear positive rate of 38.36%（140/365）, exhibited statistical difference（χ2=118.41, P〈0.05）. Conclusions Serum TB- Ig G antibody test is a rapid, simple, valuable,relatively sensitive and specific method fordiagnosis of tuberculosis.