拉莫三嗪在丙戊酸治疗无效的癫痫患者中的应用价值

Lamotrigine,valproic acid in an invalid value in the treatment of epilepsy

目的探讨拉莫三嗪在丙戊酸治疗无效的癫痫患者中的应用价值。方法运用随机抽样的方法选取本院2013年1月—2014年9月收治的80例丙戊酸治疗无效的癫痫患者,依据随机数字表法将这些患者分为研究组和对照组各40。对照组患者给予单纯拉莫三嗪治疗,研究组给予患者拉莫三嗪联合丙戊酸治疗,然后对两组患者的临床疗效、拉莫三嗪血药浓度及不良反应发生情况进行统计分析。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果研究组患者治疗的总有效率90.0%(36/40)显著高于对照组70.0%(28/40),差异有统计学意义(P<0.05);拉莫三嗪血药浓度(8.61±2.93)μg/ml显著高于对照组(3.81±1.17)μg/ml,差异有统计学意义(P<0.05);不良反应发生率20.0%(8/40)显著低于对照组45.0%(18/40),差异有统计学意义(P<0.05)。结论拉莫三嗪在丙戊酸治疗无效的癫痫患者中具有较高的应用价值,值得推广。

Objective To explore the application value of lamotrigine is invalid in valproie acid therapy in patients with epi- lepsy. Methods Using random sampling method to select our hospital in January 2013 to September 2014 with invalid val- proic acid therapy in 80 patients with epilepsy, according to the random number table method, these patients were divided into study group（ n = 40） and control group（ n = 40）. The control group were only given lamotrigine treatment, study group patients given lamotrigine combined with valproate treatment, then the clinical effect,the two groups of patients with lam-otrigine serum coneentrafion and the oeeurrenee of adverse reactions for statistical analysis. Count data was processed by t - test,Measurement data by chi - square test, P 〈 0.05 was considered statistically significant. Results The results of the study have total effective rate was 90% （ 36/40 ） in treatment groups, which was significantly higher than that in control group（ P 〈 0.05 ）, LTG serum concentrations was （ 8.61±2.93 ） g/ml, whieh was significantly higher than that in control group with （3.81±1.17 ）g/ml （P 〈 0.05 ） , the adverse reaction rate was 20% （8/40）, which was significantly lower than that of control group （ P 〈 0.05 ）. Conclusions It has a higher application value in conclusion lamotrigine valproate treatment is invalid in epileptic patients, and it is worthy of promotion.