比索洛尔治疗高血压左室肥厚的临床疗效及对室性心律失常的影响

Clinical Effect of Bisoprolol on Hypertensive Left Ventricular Hypertrophy and Its Impact on Ventricular Arrhythmias

目的探究比索洛尔治疗高血压左室肥厚的临床疗效及对室性心律失常的影响。方法选取2011年1月—2014年6月海丰县彭湃纪念医院收治的56例高血压左室肥厚患者,随机分为对照组和观察组,每组28例。对照组患者给予常规降压治疗,观察组患者在对照组基础上加用比索洛尔口服治疗。比较两组患者治疗前后左室舒张末内径(LVDd)、左室后壁厚度(LVPWT)、V2导联T波峰-末间期(Tp-e间期)、QT离散度(QTd)、室性心律失常发生率及不良反应发生率。结果两组患者治疗前LVDd、LVPWT比较,差异无统计学意义(P>0.05);观察组患者治疗后LVDd、LVPWT均小于对照组(P<0.05)。两组患者治疗前V2导联Tp-e间期、QTd和室性心律失常发生率比较,差异无统计学意义(P>0.05);观察组患者治疗后V2导联Tp-e间期、QTd均短于对照组,室性心律失常发生率低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论比索洛尔治疗高血压左室肥厚的临床疗效确切,可有效减轻患者左室肥厚程度,防治心律失常,改善预后。

Objective To investigate the clinical effect of bisoprolol on hypertensive left ventricular hypertrophy and its impact on ventricular arrhythmias. Methods A total of 56 patients with hypertensive left ventricular hypertrophy were selected in Pengpai Memorial Hospital of Haifeng County from January 2011 to June 2014,and they were randomly divided into control group and observation group, each of 28 cases. Patients of control group were given conventional antihypertensive therapy,while patients of observation group were given extra bisoprolol based on the treatment of control group. Left ventricular end - diastolic diameter （ LVDd ）, left ventricular posterior wall thickness （ LVPWT ）, Tpeak - Tend interphase （ Tp - e interphase） of V2 lead, QT dispersion （ QTd ）, incidence of ventricular arrhythmias and adverse reactions were compared between the two groups before and after treatment. Results No statistically significant differences of LVDd,LVPWT,Tp-e interphase of V2 lead,QTd and incidence of ventricular arrhythmias was found between the two groups before treatment（ P〉0. 05）;LVDd and LVPWT of observation group were smaller than those of control group after treatment（P〈0. 05）,while Tp-e interphase of V2 lead, QTd were shorter, incidence of ventricular arrhythmias was lower （ P 〈0. 05 ）. No statistically significant differences of incidence of adverse reactions was found between the two groups after treatment （ P 〉 0. 05 ）. Conclusion Bisoprolol has certain clinical effect on hypertensive left ventricular hypertrophy,can effectively relieve the severity of left ventricular hypertrophy,reduce the incidence of ventricular arrhythmias and improve the prognosis.