老叶茶叶含片制备工艺研究

Preparation Technology of Buccal Tablets Containing Old Tea Leaf Extract

目的:采用湿法制粒制备茶叶口含片并优化其制备工艺。方法:通过单因素试验对各种辅料的用量进行了考察;以口感、崩解时限作为考察指标,采用正交试验设计法优化处方。结果:最佳处方为老叶茶叶提取物30 g、甘露醇60 g、PEG6000 20 g、阿斯巴甜10 g、柠檬酸10 g、薄荷脑1 g。所制得口含片外观、硬度、崩解时限等指标均符合药典规定。结论:该茶叶含片的制备工艺合理可行。

Objective：To prepare old tea buccal tablets using wet granulation method and optimize the preparation technology. Methods：The amount of each adjuvant was studied by single factor experiments, and the formula of the buccal tablets was optimized by the orthogonal experiments using taste and disintegration time as indices. Results：The optimal formula was composed of old tea ex-tract 30 g,mannitol 60g,PEG6000 20 g,aspartame 10 g,citric acid 10 g and menthol crystal 1 g. All the tested indices including ap-pearance, hardness and disintegration time met the requirements described in Chinese pharmacopeia. Conclusion： The preparation technology is reasonable and feasible for the industrial production.