雷贝拉唑联合气滞胃痛颗粒治疗反流性食管炎的疗效及对患者血清胃泌素、血浆胃动素水平的影响

Clinical Effect of Qizhi Weitong Granules Combined with Rabeprazole in the Treatment of Reflux Esophagitis and Influence on the Levels of Gastrin and Motilin

目的:观察雷贝拉唑联合气滞胃痛颗粒治疗反流性食管炎的临床疗效及对患者血清胃泌素(GAS)、血浆胃动素(MOT)水平的影响。方法:反流性食管炎患者80例随机分为观察组与对照组各40例。对照组予雷贝拉唑胶囊20 mg,po,qd(早上空腹服用);观察组在对照组基础上加用气滞胃痛颗粒5 g,po,tid,两组均连续服用4周。观察两组的临床症状与内镜下疗效,比较治疗前后两组患者GAS、MOT水平的变化。结果:两组临床症状与内镜下疗效比较,观察组总有效率分别为95.0%和92.5%,均高于对照组(P<0.05)。两组治疗后GAS、MOT水平均治疗前显著提升(P<0.05),且观察组水平明显高于对照组(P<0.05)。结论:雷贝拉唑联合气滞胃痛颗粒治疗反流性食管炎具有较好的临床疗效,且显著提高GAS、MOT水平,值得临床上广泛应用。

Objective：To explore the clinical effect of Qizhi Weitong granules combined with rabeprazole in the treatment of reflux esophagitis and the influence on the levels of gastrin and motilin. Methods：Totally 80 cases of patients with reflux esophagitis were se-lected, and then randomly divided into the observation group and the control group with 40 cases in each. The control group was treated with rabeprazole, and the observation group was treated with Qizhi Weitong granules additionally. After 4-week treatment, the clinical effect and the influence on the levels of gastrin and motilin in the two groups were compared. Results：By comparing the clinical effect and endoscopic curative in the two groups, the total effective rate of the observation group was 95. 0% and 92. 5%, which was obvious-ly higher than that of the control group. Compared with those before the treatment, the levels of gastrin and motilin in the two groups were significantly improved after the treatment, and the improvement of the observation group was obviously higher than that of the con-trol group with statistically significant difference （P〈0. 05）. Conclusion： Qizhi Weitong granules combined with rabeprazole in the treatment of reflux esophagitis is effective, which can greatly improve the levels of gastrin and motilin and is worthy of further clinical application.