草分支杆菌制剂加化疗与单纯化疗对非小细胞肺癌治疗的比较

Clinical comparison between Mycobac-terium pheli preparation plus chemoth- erapy and only chemotherapy for advanced non-small cell lung cancer

目的 :观察草分支杆菌制剂对化疗期间中、晚期非小细胞肺癌病人免疫功能、疗效、生活质量、不良反应的影响。方法 :81例中、晚期非小细胞肺癌病人随机分为A ,B 2组 ,A组 (4 2例 )采用草分支杆菌制剂加化疗 ,B组(3 9例)采用单纯化疗 ,2组病例在治疗前后测定外周血T淋巴细胞亚群 (CD3 ,CD4,CD4/CD8)和NK细胞活性 ,并以正常人 (3 0例 )作为对照 ,对疗效、生活质量及不良反应进行评价。结果 :治疗后A组的CD3 ,CD4,CD4/CD8和NK细胞活性明显高于治疗前 ;CD8明显低于治疗前 (P <0 .0 1或P <0 .0 5 ) ,而B组无明显变化 (P >0 .0 5 ) ,A ,B 2组的有效率分别为 41 %和 3 3 % (P >0 .0 5 ) ,生活质量A组高于B组 (P <0 .0 5 ) ,白细胞减少及恶心呕吐反应B组高于A组 (P <0 .0 5 )。结论 :草分支杆菌制剂可以提高肿瘤病人的免疫功能、改善生活质量。

AIM: To observe the immunomodulatory functions, the therapeutic effect, change of quality of life, and adverse reactions of Mycobactrium pheli preparation in advanced non small cell lung cancer (NSCLC) patients during chemotherapy. METHODS: Eighty one patients with advanced NSCLC were randomly divided into NSCLC chemotherapy plus Mycobactrium pheli preparation goup A (forty two patients) and only chemotherapy group B(thirty nine patients). The peripheral blood T lymphocyte subsets(CD 3,CD 4,CD 8,CD 4/CD 8) and natural killer (NK) cell activity of patients in both groups were measured before and after treatment, while compared with normal control (thirty patients). The immune functions, the effect of treatment, quality of life, and adverse reactions were observed. RESULTS: After treatment the blood T cell levels (CD 3,CD 4,CD 8,CD 4/CD 8) and NK cell activity in group A increased, CD 8 reduced ( P< 0.05 ). That in group B had no obvious change ( P>0.05 ). The objective response rate(CR+PR) was 41 % in group A, compared to 33 % in group B( P> 0.05) . Quality of life in group A was higher than that in group B ( P<0.01) . Leukopenia, nauseu and vomiting in group B were more serious than those in group A ( P<0.05). CONCLUSION: The results show that Mycobactrium pheli preparation can obviously enhance the immunity, improve life quality of the patients, and decrease adverse reaetions of chemotherapy.