局部应用氨甲环酸及阿米卡星预防扁桃体切除术后出血

Topical application of tranexamic acid and amikacin in preventing hemorrhage after tonsillectomy

目的 :观察局部应用氨甲环酸及阿米卡星预防扁桃体切除术后出血的效果。方法 :对照组1 5 3例 (男性 78例 ,女性 75例 ,年龄 2 6a±s 3a)用2 %利多卡因 1 0mL加入氯化钠注射液 2 0mL及0 .1 %肾上腺素 3滴作扁桃体周围浸润麻醉。 2 2 9例 (男性 97例 ,女性 1 3 2例 ,年龄 2 8a± 4a)为观察组 ,用药在对照组基础上加氨甲环酸 0 .2g及阿米卡星 0 .2 g。结果 :观察组术后出血 4例 ,出血率 1 .7% ;对照组出血 1 2例 ,出血率 7.8% ,2组病人术后出血率差异有非常显著意义 (P <0 .0 1 )。结论

AIM: To observe the effect of topical application of tranexamic acid and amikacin in preventing hemorrhage after tonsillectomy. METHODS: The contrast group one hundred and fifty three patients (M 78, F 75; age 26 a± s 3 a) accepted routine anesthesia of using 2 % lidocain 10 mL adding normorl saline 20 mL and three drops of 0.1 % epinephrine during the process of tonsillectomy. The observation group of two hundred and twenty nine patients (M 97, F 132; age 28 a±4 a) accepted local anesthesia drugs, tranexamic acid 4 mL (0.2 g) and amikacin 2 mL(0.2 g) on the basis of the contrast group in tonsillectomy. RESULTS: In the observation group, there are four patients bleeding after tosillectomy among two hundred and twenty nine patients. The rate of bleeding was 1.7 % while in the contrast group there are twelve patients bleeding among one hundred and fifty three patients. The rate of bleeding was 7.8 % ( P < 0.01). CONCLUSION: Topical application of tranexamic acid and amikacin during the process of local anesthesia can reduce the rate of hemorrhage after tonsillectomy.