硝苯地平控释片对老年高血压病人胰岛素抵抗的影响

Influence of nifedipine controlled-release tablet on insulin resistance in elderly patients with hypertension

目的 :了解硝苯地平控释片对老年高血压病人的胰岛素抵抗 (IR)的影响。方法 :60例老年高血压病人 (男性 45例 ,女性 1 5例 ,年龄 74a±s 5a) ,每日早餐后口服硝苯地平控释片 3 0～ 60mg,连续服用 8wk。于治疗前后测血压 ,空腹及餐后 2h血糖(BG) ,血胰岛素 (IS) ,计算出胰岛素敏感指数(ISI)。结果 :服药 8wk后 ,收缩压下降了 5 .0kPa± 2 .1kPa,舒张压下降了 4.9kPa± 1 .8kPa(均P<0 .0 1 ) ,空腹及餐后 2hIS下降分别为 5mU·L-1± 7mU·L-1(P <0 .0 1 ) ,6mU·L-1± 3 4mU·L-1(P >0 .0 5 ) ,ISI治疗后下降了 0 .3± 0 .4(P <0 .0 1 )。结论 :硝苯地平控释片治疗老年高血压病人不仅降压效果确切 ,而且能改善病人的IR。

AIM: To observe the influence of nifedipine controlled release tablet on insulin resistance (IR) in elderly patients with hypertension. METHODS: The levels of blood pressure, fasting and 2 h post prandial blood glucose (BG), serum insulin (IS) in sixty elderly patients with hypertension (M 45, F 15; age 74 a± s 5 a) were measured before and after treatment (30-60 mg, po , qd×8 wk) with nifedipine controlled release tablet. The insulin sensitive index (ISI) was calculated. RESULTS: The blood pressure of these patients was significantly controlled after treatment with nifedipine controlled release tablet for 8 wk. The systolic pressure decreased 5.0 kPa±2.1kPa, the diastolic pressure decreased 4.9 kPa±1.8 kPa( P <0.01). The fasting IS decreased 5 mU·L -1 ±7 mU·L -1 , the ISI decreased 0.3±0.4 ( P <0.01). CONCLUSION: To elderly patients with hypertension, nifedipine controlled release tablet can not only decease blood pressure but also improve IR.