摘要
Overview Drug-induced liver injury(DILI)due to acetaminophen overdose and idiosyncratic drug reactions usually occurs 5–90 days after exposure to the causative drug.Ninety percent of DILI cases are acute.As one of the most common non-infectious liver diseases,DILI represents a growing challenge for clinicians.According to data from WHO[1],DILI is the fifth leading cause of liver disease mortality.In China,DILI accounts for 1%–5%of hospitalized patients with liver diseases,10%of patients
Overview
Drug-induced liver injury （DILI） due to acetamino- phen overdose and idiosyncratic drug reactions usually occurs 5-90 days after exposure to the causative drug. Ninety percent of DILI cases are acute. As one of the most common non-infectious liver diseases, DILI represents a growing challenge for clinicians. According to data from WHO , DILI is the fifth leading cause of liver disease mortality. In China, DILI accounts for 1%-5% of hospitalized patients with liver diseases, 10% of patients with acute hepatitis, and 12.2% of patients with fulminant hepatitis .
