儿茶酚氧位甲基转移酶与颞下颌关节紊乱病疼痛关联性研究进展

Research progress about the relationship of catechol-O-methyltransferase with chronic pain in temporomandibular joint disorders

颞下颌关节紊乱病(TMD)是口腔科难治性疾病之一,严重影响患者的生活质量和身心健康,由于其危险因素众多,目前发病机制尚未完全阐明。近年来精神心理因素备受关注,其对TMD发生的影响机制也十分复杂。儿茶酚氧位甲基转移酶(COMT)是一个与疼痛相关的基因,研究发现其在心理应激前后咀嚼肌组织中的表达发生变化,提示TMD患者的精神心理状态和COMT基因多态性存在相关性。本文就COMT基因与TMD的发生及调节之间的相关关系等方面做一综述。

Temporomandibular joint disorders（TMD）are one of the most common and refractory diseases, and significant- ly influence living quality and physical and psychological health. The risk factors of TMD are more complex, and at pres- ent the pathogenesis has not been fully elucidated. In recent years, more people are concerned about the effect of psycho- logical factors, but the effect and mechanism are complex. In foreign literature research of catechol-O-methyhransfcrase （COMT）as a gene associated with pain shows that before and after stress the COMT gene expression changes in mastica- tory muscle tissue of patients with TMD, so it can be concluded that there are correlation between the psychological state and COMT gene polymorphism. This article focuses on the effect and adjustment mechanism of COMT gene in TMD.