银杏酚酸萃取条件的理论模拟与实验研究

Simulation and experimentation of separation condition of Ginkgolic Acids

目的 :优化银杏酚酸的萃取条件 ,使得银杏酚酸与银杏黄酮、内酯得以完全分离。方法 :对银杏叶有效成分的萃取过程的计算机模拟 ,结合实验验证 ,获取萃取银杏酚酸的最佳条件。结果 :pH值 =2 .5 ,水相为含 2 0 %乙醇的水溶液 ,油相为环己烷时可得到最佳萃取效果。结论 :理论模拟所得的分配比与实验值在数量级上有较大差异 。

Objective: To optimize extraction conditions to completely separate ginkgolic acids off ginkgolic flavonone glycosides and terpene lactones. Methods: A liquid liquid equilibrium model was used to simulate extracting process of active components in ginkgo biloba leaves. Results of calculation and experiment were compared to value the extraction system, and the best extracting condition was established. Results: when pH=2.5, extractant consists of 20% ethanol water solution and cyclo hexane, the best extraction efficient can be obtained. Conclusion: There is a great difference between theoretical simulating distribution ratio and experiment value in order of magnitude. However, their relative relationship is consistent.