六味地黄方超微细粉的有效成分熊果酸与丹皮酚溶出特性的研究

Study of Liuwei Dihuang ultra micro-powder on dispersing and dissolving characteristics

目的 :对六味地黄超微细粉体的化学成分溶出特性进行考察。方法 :应用HPLC图谱考察两种粉体提取时化学成分溶出特性的异同 ;对比考察六味地黄细粉及超微粉中目标成分熊果酸及丹皮酚的含量、溶出特性。结果 :两种粉体甲醇提取液HPLC在相同保留时间有相同吸收峰 ,但峰值有明显差异 ;超微粉中熊果酸及丹皮酚的含量分别较细粉高出4 4 .5 5 %和 7.6 %。结论 :六味地黄方经超微粉碎后 ,其化学成分的组成没有明显变化 。

Objective: To observe the soluble and dispersive characteristics of Liuwei Dihuang Ultra micro power. Methods: The similarity and difference between the soluble and dispersive characteristics of two powders with HPLC atlas were observed. The contents and dissolving characteristic of target compositions Ursolic acid and Paeonol of Liuwei Dihuang powder and ultra micro powder were compared and studied. Results: At the same retaining time two powders had the same absorbent peak, but the peak values of two powders had apparent difference. the ursonic acid and paeonol in ultra micro powder were 44.55% and 7.6% higher than those of the normal powder respectively. Conclusion: After Liuwei Dihuang is broken into ultra micro power, the chemical compositions do not change but the dissolving speed and contents increase greatly.