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鳖甲煎丸药理学研究 被引量:29

Pharmacological study on Biejiajian Pills
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摘要 目的 :证实鳖甲煎丸是否具有活血化瘀 ,软坚散结功能。方法 :应用血瘀、大鼠纤维化肝胶原蛋白和尿羟脯氨酸排泄量、抗肿瘤等药理模型证实其功能。结果 :(1)本品具有促羊红细胞与自身血块的吸收作用。 (2 )本品通过对肝硬变的大鼠治疗后肝胶原纤维减少和胶原蛋白含量明显低于肝硬变组 ,同时能使肝硬变大鼠尿羟脯氨酸排泄量显著性增加 ,表明药物有促进胶原纤维降解的作用 ,使已形成的肝胶原重吸收。 (3)本品有明显的抑制S180 肿瘤生长作用。结论 :本品具有活血化瘀。 Objective: To confirm whether Biejiajian Pill has the action of promoting blood circulation to remove blood stasis, softening the hard lumps and dispelling the nodes. Methods: The blood stasis model, anti tumor model, the model of collagen and urinary hydroxyproline evacuating from fibrous liver of rat and the other pharmacological models were prepared to confirm the action of the pill. Results: (1) This pill has the absorption of erythrocyte and blood clot of itself. (2) After the pill being given to the rats with cirrhosis, the hepatitisfibrils decreased, the excretion of urinary hydroxyproline increased and the content of collagen of the therapeutics group was less than the control group. All of those suggested that this drug has the action of promoting the degradation of the collagen fiber and reabsorption of the hepatitis collagen. (3) This pill can apparently inhibit the proliferation of S 180 . Conclusion: The drug has the action of promoting blood circulation to remove blood stasis, softening the hard lumps and dispel the nodes.
出处 《中成药》 CAS CSCD 北大核心 2002年第7期529-532,共4页 Chinese Traditional Patent Medicine
关键词 鳖甲煎丸 活血化瘀 软坚散结 中药药理学 Biejiajian Pill, promote blood circulation to remove blood stasis, soften the hard lumps and dispel the nodes
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参考文献3

  • 1中华人民共和国卫生部药政管理局.中药新药研究指南[M].,1994.98.
  • 2王祯苓 赵元昌 等.活血化瘀药物防治实验性肝病的研究[J].中医杂志,1982,23(1):67-67.
  • 3崔小瑞 曾凡波 等.金刚藤糖浆的药理作用研究[J].中药药理与临床,1996,12:128-128.

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