中性粒细胞与淋巴细胞比值在食管鳞状细胞癌患者预后评估中的价值

Prognostic Role of Neutrophil-to-lymphocyte Ratio on the Radiotherapy of Esophageal Squamous Cell Carcinoma

目的:探讨放射治疗前外周血中性粒细胞与淋巴细胞比值(NLR)在食管鳞状细胞癌患者预后评估中的价值。方法:回顾性分析2008年5月-2011年11月在徐州医学院附属医院放疗科住院确诊为食管鳞状细胞癌的149例患者的临床资料。NLR的临界值定义为3.0,其中NLR≥3.0的32例患者设为高NLR组,NLR<3.0的117例患者设为低NLR组。观察比较两组患者的放疗近期疗效及3年生存率。结果:高NLR组患者的近期总有效率为34.4%(11/32),明显低于低NLR组患者的58.1%(68/117),差异有统计学意义(P<0.05)。高NLR组患者的3年生存率为18.8%(6/32),明显低于低NLR组患者的37.6%(44/117),差异有统计学意义(P<0.05)。结论:放射治疗前外周血NLR≥3.0提示食管鳞状细胞癌患者预后不良。

Objective：To investigate the prognostic significance of neutrophil-to-lymphocyte ratio（NLR） in patients with esophageal squamous cell carcinoma（ESCC） who received radiotherapy.Method：The clinical data of 149 patients with ESCC in Department of Radiotherapy of the Affiliated Hospital of Xuzhou Medical College from May 2008 to November 2011 were analyzed retrospectively.Based on this cut-off value of 3.0,all the patients were divided into the two groups：32 cases with NLR ≥ 3.0 were regarded as the high NLR group,117 cases with NLR〈3.0 were regarded as the low NLR group.The short-term efficacy of radiotherapy and 3-year survival rate between the two groups were observed and compared.Result：The objective response rate（RR） of the high NLR group was 34.4%（11/32）,which was significantly lower than 58.1%（68/117） of the low NLR group,the difference was statistically significant（P〈0.05）.The 3-year survival rate in the high NLR group was 18.8%（6/32）,which was significantly lower than 37.6%（44/117） of the low NLR group,the difference was statistically significant（P〈0.05）.Conclusion：The results show that NLR≥3.0 may be a prognostic marker in patients with ESCC.