肺癌患者血清铁蛋白的表达及临床意义

Expression and clinical significance of serum ferritin in patients with lung cancer

目的：探讨肺癌患者血清铁蛋白的表达及临床意义。方法收集并检测174例肺癌患者和85例肺良性病变患者术前血清铁蛋白水平，并分析血清铁蛋白水平与肺癌临床病理特征间的关系。结果肺癌患者血清铁蛋白显著高于肺良性病变患者，鳞癌、肿瘤较大、低分化和晚期的非小细胞肺癌患者血清铁蛋白分别显著高于腺癌、肿瘤较小、高-中分化和早期的患者。结论血清铁蛋白可能在肺癌的发生和进展中起到促进作用。

Objective To investigate the expression and clinical significance of serum ferritin in patients with lung cancer. Methods The relationship between preoperative serum ferritin level and corre-sponding clinicopathological data in 174 patients with lung cancer and 85 patients with benign pulmonary diseases was reviewed and analyzed. Results The level of serum ferritin in patients with lung cancer was significantly higher than that in patients with benign pulmonary diseases. For non-small cell lung cancer, patients with large-sized,poorly differentiated squamous carcinoma in advanced stage had higher serum ferritin levels than those with small-sized,highly or moderately differentiated adenocarcinoma in early stage. Conclusion Serum ferritin may play a promoting role in the development and malignant progres-sion of lung cancer.