妊娠合并甲型H1N1流感患者的预后随访分析

Follow-up analysis on prognosis of patients with influenza A H1N1 influenza during pregnancy

目的:研究妊娠期甲型H1N1流感对母儿的长期影响。方法:收集16例妊娠合并甲型H1N1流感患者的临床资料,随访5年后的临床症状、胸部CT检查及肺功能检测,探讨各项检查指标的变化。结果:随访5年后,16例患者存在临床慢性呼吸道症状3例,胸部CT异常8例,肺功能异常9例;轻症与重症(包括危重症)甲型H1N1流感患者的胸部CT及肺功能随访结果对比,差异有统计学意义(P<0.05)。10例新生儿未发现H1N1流感病毒感染,在随后的5年随访中,生长发育与其他婴幼儿无异。结论:妊娠合并甲型H1N1流感患者出院5年后,仍有部分患者残留胸部CT异常和肺功能障碍,应重视对此类患者临床检查,以指导长期治疗。

Objective： To research the long-term effect of influenza A HINI influenza during pregnancy on mothers and infants. Methods： The clinical data of 16 patients with influenza A HI N1 influenza during pregnancy were collected, the clinical symptoms, chest CT, and pulmonary function test after 5 years were followed up, the changes of various indexes were investigated. Results： Follow-up after 5 years found that among 16 patients, 3 patients were found with clinical chronic respiratory symptoms, 8 patients were found with chest CT abnormality, and 9 patients were found with pulmonary function abnormality. There were statistically significant differences in the follow-up results of chest CT and pulmonary function between the patients with mild influenza A H1N1 influenza and the patients with severe influenza A H1NI influenza （P〈0. 05 ） . Among 10 neonates, no one was found with influenza A H1 N1 influenza, and their growth and development were the same as the other infants during follow-up after 5 years. Conclusion： At five years after leaving the hospital, there are still some patients with abnormal chest CT and pulmonary dysfunction, clinical examination of such patients should be paid more attention to, longterm treatment should be guided.