120例0～6岁儿童血清25-羟基维生素D水平的调查

Investigation on serum 25-hydroxy vitamin D levels among 120 children aged 0-6 years old

目的：了解中山小榄地区儿童维生素D的营养状况。方法：选择2013年在广东医学院附属陈星海医院儿童保健科和儿科就诊的0~6岁120例儿童为研究对象,采用高效液相质谱法-串联质谱法进行血清25-（OH）D水平检测,并对结果进行统计学分析。结果：120例儿童25-（OH）D水平为（25.7±7.1）ng/ml,婴儿组25-（OH）D水平（31.3±7.2）ng/ml高于幼儿组的（25.7±6.2）ng/ml,幼儿组高于学龄前组的（22.8±7.1）ng/ml;男性儿童25-（OH）D水平（24.2±7.3）ng/ml低于女性儿童的（28.2±6.1）ng/ml,差异均有统计学意义（P〈0.05）。儿童25-（OH）D缺乏率为71.7%,幼儿组与学龄前组血清25-（OH）D缺乏率差异无统计学意义（P〉0.05）,但高于婴儿组缺乏率（P〈0.05）;男性儿童Vit D缺乏率73.7%与女性儿童68.2%差异无统计学意义（P〉0.05）。结论：中山小榄地区儿童25-（OH）D缺乏率较高,男性和女性缺乏率无差异,25-（OH）D水平随着儿童年龄增大而下降。

Objective： To understand the nutritional status of vitamin D in children from Xiaolan region in Zhongshan. Methods： A total of 120 children aged 0- 6 years old were selected from Department of Child Health Care and Department of Pediatrics in the hospital in 2013 ; HPLC-MS/MS was used to detect serum 25-hydroxy vitamin D levels, then the results were analyzed statistically, Results： Serum 25-hydroxy vitamin D level among the 120 children was （25.7±7. 1 ） ng,/nd on average, serum 25-hydroxy vitamin D level in infants was （31.3±7.2） ng/ml, which was higher than that in young children （25.7±6. 2 ng/ml） and preschool children （22. 8±7. 1 ng/ml） ; serum 25-hydroxy vitamin D level in boys was （24. 2±7. 3） ng/ ml, which was lower than that in girls （28.2±6. 1 ng/ml）, there were statistically significant differences （P〈0. 05） . The rate of 25- hydroxy vitamin D deficiency was 71.7%, there was no Statistically significant difference between young children and preschool children （P〉 0. 05 ）, but the rates of 25-hydroxy vitamin D deficiency in young children and preschool children were statistically significantly higher than that in infants （P〈0. 05）; there was no statistically significant difference in the rate of 25-hydroxy vitamin D deficiency between boys （73.7%） and girls （68. 2% ） （P〉0. 05） . Conclusion： The rate of 25-hydrexy vitamin D deficiency among the children in Xiaolan region is high, but there is no statistically significant difference between boys and girls, serum 25-hydr0xy vitamin D levels decrease with age.