高迁移率族蛋白 B1在多器官功能障碍综合征中炎症调控作用的研究进展

Role of HMGB1 in inflammation regulation of multiple organ dysfunction syndrome

高迁移率族蛋白B1（HMGB1）作为一个晚期炎症因子参与多器官功能障碍综合征（ MODS）的发生与发展，其与RAGE／TLRs受体的结合引发系列信号转导最终激发NF－κB的核内转移引发全身炎症反应综合征（ SIRS ）为主要机制。本文从HMGB1的几个受体以及其与MODS发生、发展的关系方面就HMGB1在MODS中炎症调控方面的作用做一综述。

As a late inflammatory factor, high mobility group protein B1 （HMGB1） participates in the occurrence and development of multiple organ dysfunction syndrome （ MODS） .HMGB1 binds to RAGE/TLRs receptor, and finally triggers series of signal transduction stimulating nuclear translocation of NF-κB for inflammation falls was the most acceptable mechanism.We make a review of HMGB1 in the regulation of inflammation of MODS, including the receptors of HMGB1 and the relationships between them.