银屑病治疗靶点及其药物研发进展

Progress of development and research on targets and therapeutic drugs for psoriasis

银屑病的发病机制未能完全阐明,近年来大量的实验和临床研究证实,银屑病可能是T细胞介导的自身免疫性疾病。这一发病过程涉及了很多靶点的激活,T细胞增殖和细胞因子的作用。目前,基于这些靶点研发治疗银屑病的新药已取得了长足的进展,本文就近年来银屑病靶向药物研究进展作一综述,为开发新的靶向药物提供参考。

OBJECTIVE The pathogenesis of psoriasis has not been completely elucidated. But extensive experimental and clinical evidences obtained in recent years suggest that psoriasis may be a T Cell mediated autoimmune disorder. The activation of targets, proliferation of T cells and effects of cytokines are involved in this disease. Development of new drugs for psoriasis which base on these targets have been made great progresses in recent years. In this paper, the psoriasis drugs developed through different targets have been reviewed to provide some references for researches on new drugs for psoriasis treatment.