我院人血白蛋白临床应用现状及用于脑梗死患者的临床疗效评价

Application of Human Albumin and Evaluation of the Clinical Efficacy of Human Albumin in the Treatment of Patients with Cerebral Infarction in Our Hospital

目的:为临床合理使用人血白蛋白提供参考。方法:回顾性调查上海交通大学附属第一人民医院2012年11月-2013年4月所有使用人血白蛋白的住院患者病历563份,对患者年龄、住院科室、用药量、用药前血清白蛋白质量浓度等进行统计分析。另回顾性选择2011年1月-2013年4月脑梗死患者79例,随机分为治疗组37例和对照组42例,两组均采用相同的支持治疗,治疗组加用人血白蛋白,治疗周期为14 d,评价两组治疗前后的神经功能缺损评分及疗效。结果:使用人血白蛋白最多的科室为普外科,其次为移植泌尿科、中医/肿瘤科、消化科等。脑梗死患者中,治疗后治疗组神经功能缺损评分改善较对照组明显,差异有统计学意义(P<0.05);治疗组有效率为89.19%,明显优于对照组的71.43%,差异有统计学意义(P<0.05)。结论:脑梗死的治疗中联用人血白蛋白较常规治疗的疗效及安全性更好。

OBJECTIVE： To provide reference for the rational use of human albumin in clinic. METHODS： Totally 563 re- cords of patients received albumin in the First Affiliated People＇s Hospital of Shanghai Jiaotong University from Nov. 2012 to Apr. 2013 were retrospectively investigated and the age, hospitalization department, dosage, mass concentration of serum albumin be- fore administrated were statistically analyzed. 79 patients with cerebral infarction from Jan. 2011 to Apr. 2013 were retrospectively selected and randomly divided into treatment group （37 cases） and control group （42 cases）. Both groups were received the same supportive treatment. Patients in treatment group were added human albumin for 14 d. The scores of neurological deficit and effica- cy were evaluated. RESULTS： Most of the patients received albumin was from the department of general surgery, followed by de- partments of transplantation urology, TCM/oncology and gastroenterology, etc. For the patients with cerebral infarction, compared with control group, after treatment, the scores of neurological deficit in treatment group was significantly improved with significant difference （P〈0.05）, the effective rate was 89.19%, significantly better than control group （71.43%） with significant difference （P〈0.05）. CONCLUSIONS： The combination use of human albumin has better efficacy than routine treatment in the treatment of cerebral infarction with better safety.